Kisspeptin for Fertility

In females it can prevent menstruation which leads to other hormones dysfunction and absence of ovulation. Sometimes, just one injection of kisspeptin can trigger ovulation, which can allow for artificial insemination and in vitro fertilization using the woman’s eggs. This is an essential nutrient for your body to function properly and fight disease. It has to transform it into activated forms, like methylcobalamin, which is the most effective for use by the cells.

Apart from the well-established role of kisspeptin in the regulation of reproductive functions, recent data described its action in the control of metabolism. Of particular interest for the review is the population of Kp neurons localized in the arcuate nucleus of the hypothalamus, the site of the brain where reproductive and metabolic cross talk occurs. Beyond the brain, Kp is expressed in peripheral tissues involved in metabolic functions.

This is suppressed in cases of exogenous testosterone or androgen use, and in turn, suppresses LH . The potential difficulty with this is the need to take GnRH multiple times per day (potentially kisspeptin-10 as well) for optimal results. An alternative solution is to start kisspeptin-10 before coming off of TRT.

The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Ideally, the patient will take his kisspeptin-10 dosage concurrently with TRT, typically 2-3 times per week with a standard injection of .1-.2mL per injection at each interval. Kisspeptin-10’s benefit of increased LH concentrations in the blood can mitigate one of the common side effects of poorly-performed TRT . “Testicular atrophy” is a condition in which the testicles shrink due to the unbalanced endocrine system.

Along with increased secretory mass in individual pulses, this increase in pulse frequency resulted in pulsatile secretion contributing to a higher proportion of total LH secreted. Data from other investigators have not shown that GnRH pulse frequency is increased by an acute bolus of kisspeptin , indicating the need for continuing kisspeptin stimulation to study its influence on GnRH pulse frequency. Systemic administration of kisspeptin-10 in our study prevents us from concluding whether this increase in LH pulse frequency is mediated by a direct effect on GnRH neurons or through stimulation of the hypothalamic pulse generator .

The 2.5-fold increase in serum LH from baseline observed after kisspeptin bolus administration in our study is comparable with that observed in men administered equimolar doses of kisspeptin-54 as short infusions . Moreover, as in human studies using kisspeptin-54 , the stimulatory effect of kisspeptin-10 on LH secretion in our study was also markedly more pronounced than that on FSH secretion. Early animal studies suggested stimulatory pretihom percussion massage gun effects on LH and testosterone secretion were seen only with the longer kisspeptin peptide, kisspeptin-54, and not shorter forms . However, in vivo rodent data have subsequently shown equal potency of kisspeptin-10 and kisspeptin-54 , and in in vitro binding assays, both peptides show equal affinity at the KISS1R . Our results demonstrate that the 10 amino acid form of kisspeptin is a potent LH secretagogue in vivo in humans.

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